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     韩淑琴

        博士, 副教授,硕士生导师

       办公室:南校区化学楼217

       邮箱:chem-hshq@imu.edu.cn





 

教育背景

1996-2000:内蒙古师范大学 化学系本科,获理学学士学位

2000-2003:皇冠welcome体育登录入口 硕士研究生,获理学硕士学位

2004-2007:日本北见工业大学 工学部 博士研究生,获工学博士学位

 

工作经历

2007-2008:日本北见工业大学 博士后

2009-2010:皇冠welcome体育登录入口 讲师

2011-至今:皇冠welcome体育登录入口 副教授

 

研究领域

1.      基因递送载体的设计制备及性能研究

2.      蒙药化学成分的鉴定与生物活性研究

 

教学

主讲皇冠welcome体育登录入口《无机化学实验》课程,研究生《无机物波谱学》课程,生命科学学院《大学化学1》课程

 

研究项目

1. 内蒙古自治区自然科学基金面上项目,2019MS02009, -肽树枝状大分子 基因载体的制备及其基因递送功能研究,2019/09- 2022/1210万,在研,主持

2. 国家自然科学基金面上,21875124,基于凝胶多糖的多功能细胞支架的设计及其抗肿瘤免疫治疗活性的研究,2019/01-2022/1265万,在研,参与

3. 国家自然科学基金青年,51103067ATRP法制备葫芦脲[6]接枝壳聚糖智能药物载体及其非供价键表面修饰研究,2012/01-2014/1225万,已结题,参与

4. 留学回国人员启动基金项目,112103,新型降脂化合物:水溶性胡椒酸衍生物的合成与药效研究,2011/01-2013/124万,已结题,主持

5. 国家自然科学基金地区,21067006,应用数据挖掘技术研究水环境中化学污染物的解析和辨识,2011/01-2013/1233万,已结题,参与

6. 内蒙古大学博士启动基金,Z00901252009/11-2011/125万,已结题,主持

 

代表性成果

发表SCI期刊学术论文20余篇。

第一作者及通讯作者论文:

1.       Mingming B., Ehexige E., Jing X., Tsogzolmaa G., Shuqin H., Huricha B., “Oxidized curdlan activates dendritic cells and enhances antitumor immunity”, Carbohydrate Polymers, 2021, 264(117988), 1-11.

2.       Qingming B., Tsogzolmaa G., Qiburi Q., Mingming B., Shuqin H., Huricha B., “AMP functionalized curdlan nanoparticles as a siRNA carrier: Synthesis, characterization and targeted delivery via adenosine A2B receptor”, International Journal of Biological Macromolecules, 2021, 193: 866-873.

3.       Muqier M., Hai X., Xiang Y., Yifeng L., Mingming B., Qingming B., Shuqin H., Huricha B., “Synthesis of PEGylated cationic curdlan derivatives with enhanced biocompatibility”, Journal of Biomaterials Science, Polymer Edition, 2021, 1: 1-16.

4.       Ehexige E., Mingming B., Purevbat B., Xiang Y., Hai X., Shuqin H., Huricha B., Silencing of STAT3 via peptidomimetic LNP mediated systemic delivery of RNAi downregulates PD-L1 and inhibits melanoma growth, Biomolecules, 2020, 10(285): 10(285): 1-13.

5.       Shuqin H., Tsogzolmaa G., Qingming B., Takashi Y., Huricha B., “Sugar functionalized synergistic dendrimers for biocompatibledelivery of nucleic acid therapeutics”, Polymers, 2018, 10(1034): 1-11.

6.       Shuqin H., Taisei K., Hideki N., Takashi Y. “Synthesis of a new amphiphilic glycodendrimer with antiviral functionality”, Carbohydrate Polymers, 2012, 90, 1061-1068.

7.       Shuqin H., Dai Y., Taisei K., Hideki N., Toshiyuki U., Takashi Y., “Sulfated oligosaccharide cluster with polylysine core scaffold as a new anti-HIV dendrimer”, Carbohydrate Polymers, 2010, 80, 1111-1115.

8.       Shuqin H., Yuji K., Kazuyuki H., Hidkki N., Takashi Y., “Ring-opening polymerization of benzylated 1, 6-anhydro-b-D-lactose and specific biological activities of sulfated (1→6)-a-D-lacto- pyranans”, Journal Polymer Science Part A: Polymer Chemistry, 2009, 47, 913-924.

9.       Shuqin H., Takashi Y., Toshiyuki U., “Synthesis of a new polylysine-dendritic oligosaccharide with alkyl spacer having peptide linkage”, Carbohydrate Polymers. 2007, 69, 436-444.

10.   Shuqin H., Huricha B., Kazuyuki H., Takashi Y., Toshiyuki U., “Synthesis of new spherical and hemispherical oligosaccharides with polylysine core scaffold”, Carbohydrate Polymers. 2007, 68, 26-34.

其它论文:

1.       Hai X., Shuqin H., Huricha B., “Regulation of microglia polarization via mannose receptor-mediated delivery of siRNA by ligand-functionalized DoGo LNP”, Journal of Biomaterials Science, Polymer Edition, 2021, 11(52), 32549-32558.

2.       Tseyenkhorloo E.O., Tsogzolmaa G., Jargalmaa Z., Shuqin H., Gereltu B., Huricha B., “Alkylation enhances biocompatibility and siRNA delivery efficiency of cationic curdlan nanoparticles”, International Journal of Biological Macromolecules, 2020, 143:118-125.

3.       Tsogzolmaa G., Shuqin H., Agula H., Huricha B., “Receptor-mediated delivery of therapeutic RNA by peptide functionalized curdlan nanoparticles”, Int J Biol Macromol., 2019,126: 633–640.

4.       Suvdmaa T., Shuqin H., Masashi K., Chunjie M., Taisei K., Hideki N., Takashi Y., “Isolation and antiviral activity of water-soluble cynomorium songaricum rupr polysaccharides”, J. Asian. Nat. Prod. Res., 2016, 18(2), 159-171.

5.       Shuqin H., Takashi Y., “Preparation of loading function of dendrimers to drug molecules and nucleic acid”, 65th SPSJ Annual Meeting Polymer Preprints, May 25, 2016, Kobe, Japan.

6.       Tegshi M., Budragchaa D., Taisei K., Hideki N., Koji I., Naoki Y., Shuqin H., Takashi Y., “Chemically sulfated natural galactomannans with specific antiviral and anticoagulant activities”, Int J Biol Macromol., 2016, 89, 415-420.

7.       Davaanyam B., Shiming B., Taisei K., Hideki N., Shuqin H., Takashi Y., “Synthetic galactomannans with potent anti-HIV activity”, Carbohydr. Polym., 2015, 130, 233-242.

8.       Li Y., Shuqin H., Uryu T., Takashi Y., Toshiyuki U., “Synthesis of new spherical polylysine oligosaccharide dendrimers with C6 methylene spacer”, Sen-I Gakkaishi, 2015, 71(1), 10-17.

9.       Tegshi M., Shuqin H., Kanamoto T, Hidkki N., Takashi Y., “Synthesis and specific influenza A virus-adsorptive functionality of alkyl curdlan sulfate-coated membrane filter”, J. Polym. Sci. Part A: Polym. Chem., 2011, 49, 3241-3247.

10.   Dai Y., Shuqin H., Narita K, Kazuyuki H., Takashi Y., “Synthesis of oligosaccharide -branched ribofuranan by ring-opening polymerization of a new anhydro ribo-trisaccharide monomer”, Macromol. Biosci., 2009, 9, 687-693.

11.   Takashi Y., Rong L., Shuqin H., Hattori K., Katsuta. T., Kei-ichi. S., Masamitsu F., “Laccase-catalyzed polymerization of lignocatechol and affinity on proteins of resulting polymers”, J. Polym. Sci. Part A: Polym. Chem., 2009, 47, 824-832.

 

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